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職位描述
Key Responsibilities
? Design and develop methods for synthesis, purification, and analysis of chemically modified oligonucleotides.
? Utilize analytical instrumentation such as HPLC, and/or LC-MS for the analysis of both crude and purified oligonucleotide products. Effectively troubleshoot synthetic/process issues and independently find solutions.
? Improve upon and/or develop new methods and automation for the downstream processing of synthetic oligonucleotides and their subsequent analysis/purification and annealing into siRNA duplexes.
? Analyze, interpret, and organize analytical data to present to team members.
? Contribute to the organization of the synthesis lab including upkeep of lab instrumentation, day-to-day operations, and adherence to EHS rules and regulations.

任職要求
Qualifications
? Bachelor's or master’s degree in chemistry, Biochemistry, or related field with 3+ years of experience in an industrial or academic lab setting.
? Excellent background in organic chemistry and hands on experience with oligonucleotides solid-phase synthesis.
? Experience with instrumentation such as analytical and prep HPLC, LC-MS, NMR, etc. is required.
? Good understanding of chromatography and experience in developing methods (IEX/RP HPLC, LC-MS) is a plus.
? Ability to function within a highly interdisciplinary environment is a must.
? Excellent written and oral communication skills, the ability to multitask, and the ability to work within a team and/or independently are required.